Dual assay for evaluating activity and cytotoxicity of compounds in the same population of cells

摘要

Methods are provided for evaluating the activity and cytoxicity of a compound in the same population of cells. These dual activity/cytoxicity methods are amenable for use in a high-throughput format. Also provided are humanized Renilla luciferase genes useful for the dual activity/cytoxicity assays and for use in a variety of reporter constructs.