发明名称 |
MODIFIED FVIII HAVING REDUCED IMMUNOGENICITY THROUGH MUTAGENESIS OF A2 AND C2 EPITOPES |
摘要 |
Specific amino acid loci of human fVIII interact with inhibitory antibodies of hemophilia patients after being treated with fVIII. Modified fVIII is disclosed in which the amino acid sequence is changed by multiple substitutions in human fVIII A2 and C2 domains. The modified fVIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory antibodies. |
申请公布号 |
WO2005046583(A2) |
申请公布日期 |
2005.05.26 |
申请号 |
WO2004US35536 |
申请日期 |
2004.10.25 |
申请人 |
EMORY UNIVERSITY;LOLLAR, JOHN, S. |
发明人 |
LOLLAR, JOHN, S. |
分类号 |
A61K;C07H21/04;C07K14/755;C07K16/36;C12P21/04;G01N33/53 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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