METHOD FOR EXAMINING DISEASE CAUSED BY LIPID DYSBOLISM USING POLYMORPHISM ON NARC-1 GENE, AND APPLICATION OF THE POLYMORPHISM FOR DRUG DESIGN

摘要

PROBLEM TO BE SOLVED: To provide a method for examining diseases caused by lipid dysbolism through finding a polymorphism or haplotype associated with lipid metabolism in the intron domain or exon domain of NARC-1 gene and using the polymorphism or haplotype as an indicator.

SOLUTION: The method comprises the following: The total exon for NARC-1 gene discovered in an autosomal dominant hyperlipemic family is sequenced and it is found that intron 1 C-161T and 1474V genotypes affect serum total cholesterol level and serum LDL(low-density lipoprotein) cholesterol level. In the presence/absence of the genotypes as an indicator, diseases associated with the lipid metabolism for a relevant subject can be examined.

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