发明名称 |
TREATMENT AND PREVENTION OF LIVER DISEASE ASSOCIATED WITH PARENTERAL NUTRITION (PN) |
摘要 |
The present invention is based on the discovery that parenteral nutrition (PN) induced liver disease, e.g. fatty liver disease, can be prevented and even reversed by administration of primarily omega-3-fatty acid with PN rather than the adminstration of the standard intravenous lipid emulsions that contain primarily plan derived omega-6 fatty acid. Thus, the present invention provides a method for treating or preventing liver disease in a human patient obtaining nutritional support through PN. The method comprises intravenous administration of an effective amount of an omega-3-fatty acid emulsion to the patient, wherein the patient is not administered phytosterols or plant derived fatty acids, e.g. omega-6 fatty acids derived from a plant source, and wherein the administration of the omega-3-fatty acid emulsion to the patient is for a period greater than three weeks. Preferably, the administration is for a period of greater than six weeks. More preferably, the administration is for a period greater than three months. |
申请公布号 |
WO2005046669(A1) |
申请公布日期 |
2005.05.26 |
申请号 |
WO2004US37993 |
申请日期 |
2004.11.05 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;PUDER, MARK;GURA, KATHLEEN, M. |
发明人 |
PUDER, MARK;GURA, KATHLEEN, M. |
分类号 |
A23L1/29;A23L1/30;A61K9/00;A61K9/107;A61K31/202;A61K31/23 |
主分类号 |
A23L1/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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