发明名称 |
Inhibition of retroviral replication through modulation of the host cell ubiquitylation |
摘要 |
The present invention relates to methods of inhibiting replication of a retrovirus, such as human immunodeficiency virus (HIV), by inhibiting modulation of ubiquitylation of a host cell substrate protein, such as CEM15 of CD4, where ubiquitylation modulation is mediated by a retroviral protein, such as HIV Vif or Vpu. The invention also relates to screening methods for identifying agents that inhibit viral replication by inhibiting retroviral protein-mediated modulation of host cell ubiquitylation.
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申请公布号 |
US2005112562(A1) |
申请公布日期 |
2005.05.26 |
申请号 |
US20040985804 |
申请日期 |
2004.11.10 |
申请人 |
RIGEL PHARMACEUTICALS, INC. |
发明人 |
PAYAN DONALD G.;JENKINS YONCHU |
分类号 |
A61K38/17;A61K39/21;C07K1/00;C12N;C12Q1/70;G01N33/569;(IPC1-7):C12Q1/70 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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