发明名称 EQUINE P-SELECTION GLYCOPROTEIN LIGAND-1 AND USES THEREOF
摘要 A novel equine P-selection glycoprotein ligand-1 (ePSGL-1) is disclosed having the amino acid sequence set forth in SEQ ID NO:2. DNA sequence encoding the ePSGL-1 are also disclosed, along with vectors, host celles, and methods of making the ePSGL-1. The invention further provides methods for preventing or reducing acute inflammatory response in an equine subject by administering ePSGL-1 and flagments thereof (e.g., an ePSGL-1-Ig fusion protein). The invention also provides methods for identifying compounds capable of reducing or preventing damage to tissue or organs caused by acute inflammatory response in an equine subject.
申请公布号 WO2005047320(A2) 申请公布日期 2005.05.26
申请号 WO2004US37844 申请日期 2004.11.12
申请人 WISCONSIN ALUMNI RESEARCH FOUNDATION;DARIEN, BENJAMIN J. 发明人
分类号 A61K38/00;C07H21/04;C07K14/705;C07K16/18;C12N9/10;C12Q1/68;G01N33/68 主分类号 A61K38/00
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