发明名称 |
Method for enhancing mutant enzyme activities in gaucher disease |
摘要 |
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity. |
申请公布号 |
US2005113415(A1) |
申请公布日期 |
2005.05.26 |
申请号 |
US20040989258 |
申请日期 |
2004.11.16 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY |
发明人 |
FAN JIAN-QIANG;ISHII SATOSHI;ASANO NAOKI |
分类号 |
A61K31/445;A61K31/4465;A61K31/7008;A61K31/7042;A61K31/7052;A61K31/706;A61P43/00;C07D207/12;C07D211/46;C07H17/02;C12N9/40;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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