COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A NEUROTROPHIC FACTOR-MODULATING AGENT FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM MEDIATED DISORDERS

摘要

The present invention provides compositions and methods for the treatment of central nervous system mediated disorders. More particularly, the invention provides a combination therapy for the treatment of a central nervous system mediated disorder comprising the administration to a subject of a neurotrophic factor-modulating agent in combination with a cyclooxygenase-2 selective inhibitor.