Test system for the identification of APJ receptor ligands

摘要

The present invention refers to a test system for the identification of a ligand for angiotension receptor like-1 (APJ receptor) comprising an APJ receptor or a functional variant thereof and a Galphaq or a Galphal protein or a hybrid protein which is assembled from portions of different G proteins like Galphaq or Galphal proteins, a method of screening an APJ receptor ligand using the test system, a method for producing a medicament, a method for diagnosis and prognosis of a heart disease and a kit usable for detection or prognosis of a heart disease.