Identification and isolation of novel polypeptides having PDZ domains and methods of using same

摘要

The invention described herein encompasses the identification and isolation of polypeptides having PDZ domains or functional equivalents thereof. Various methods of use of these polypeptides are described including, but not limited to, targeted drug discovery. The invention also includes nucleotide sequences encoding novel PDZ domains and the proteins encoded thereby. The invention additionally provides for various peptide recognition units that bind to PDZ domains. The present invention also encompasses nucleotide sequences encoding novel WW domains and the polypeptides encoded thereby.