SUSTAINED-RELEASE PHENYLALANINE DERIVATIVE PREPARATION FOR ORAL ADMINISTRATION

摘要

A sustained-release preparation for oral administration which is a coated preparation or matrix preparation and contains as an active ingredient either a phenylalanine compound represented by the formula (1) [wherein A represents the formula (2), etc.; B represents alkoxy, etc.; E represents hydrogen, etc.; D represents substituted phenyl, etc.; T, U, and V each represents carbonyl, etc.; Arm represents a benzene ring, etc.; R1 represents alkyl, etc.; R2, R3, and R4 are the same or different and each represents hydrogen, substituted amino, etc.; and J and J' each represents hydrogen, etc.] or a pharmaceutically acceptable salt of the compound. Although this active ingredient has a relatively short half-life period in plasma, the preparation has long-lasting effectiveness.