Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms

摘要

An oral pharmaceutical composition, comprising one or more positively charged, highly water-soluble pharmaceutically active agents such as trospium chloride, and one or more polymers containing polarized oxygen atoms, whereby the active agent(s) form an ion-dipole interaction with the polymer(s) that may be used for an immediate release system, an extended release system or a delayed release system.