发明名称 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
摘要 The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula I are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
申请公布号 US2005113344(A1) 申请公布日期 2005.05.26
申请号 US20040965215 申请日期 2004.10.15
申请人 INCYTE CORPORATION 发明人 LI YUN-LONG;ZHUO JINCONG;BURNS DAVID;YAO WENQING;JALLURI RAVI KUMAR
分类号 A61K31/195;A61K31/4166;A61K31/426;A61K31/66;C07D207/08;C07D211/32;C07D213/50;C07D241/04;C07D401/06;C07D401/08;C07D403/08;C07D405/08;C07D405/14;C07D413/08;(IPC1-7):A61K31/66;A61K31/416 主分类号 A61K31/195
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