发明名称 |
SINGLE NUCLEOTIDE POLYMORPHISMS SENSITIVELY PREDICTING ADVERSE DRUG REACTIONS (ADR) AND DRUG EFFICACY |
摘要 |
The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes. <??>The present invention further relates to isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response, the polynucleotide is selected from the group comprising: SEQ ID 1-168 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for PA gene polypeptide and with or without the PA gene promoter sequence. |
申请公布号 |
EP1532277(A2) |
申请公布日期 |
2005.05.25 |
申请号 |
EP20030792358 |
申请日期 |
2003.08.18 |
申请人 |
SIEMENS HEALTHCARE DIAGNOSTICS GMBH |
发明人 |
SCHWERS, STEPHAN;KALLABIS, HARALD;STROPP, UDO |
分类号 |
A61K48/00;C07K14/47;C12N15/63;C12Q1/68;G01N33/50;G01N33/68;(IPC1-7):C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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