| 摘要 |
The invention comprises pyridoxalyl disulphide of formula <FORM:1005649/C2/1> The compound may be prepared (a) from a compound of formula <FORM:1005649/C2/2> where Z is a group which may be converted into an aldehyde group, by forming the aldehyde group; (b) from a compound of formula <FORM:1005649/C2/3> where X is halogen, by reaction with an inorganic disulphide; and (c) from a compound of formula <FORM:1005649/C2/4> or of formula <FORM:1005649/C2/5> by oxidation with manganese dioxide. In examples, pyridoxalyl disulphide is obtained by reacting pyridoxalyl disulphide tetraethyl acetal with hydrochloric acid with citric acid and with an acidic ion-exchanger, by reacting bis-4-[(31,41 - dimethyl - 51 - phenyl - oxazolidinyl - 21) - 5 - hydroxy - 6 - methyl - pyridyl - (3) - methyl]-disulphide with hydrochloric acid, by reacting pyridoxalyl disulphide dioxime with hydrochloric acid, by reacting pyridoxalyl disulphide dibetaine sulphonic acid with formaldehyde, by reacting pyridoxalyl disulphide diphenyl-hydrazone with dinitrobenzaldehyde in hydrochloric acid, by reacting pyridoxolyl disulphide with pyrolusite in sulphuric acid, and by reacting 2-methyl-3-hydroxy-4-formyl-5-chloromethyl-pyridine with sodium disulphide. Pharmaceutical compositions comprise pyridoxalyl disulphide and a carrier, e.g. water, vegetable oils, lactose, starch, magnesium stearate and talc.
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