发明名称 CD10-activated prodrug compounds
摘要 The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.
申请公布号 US6897034(B2) 申请公布日期 2005.05.24
申请号 US20020167627 申请日期 2002.06.11
申请人 MEDAREX, INC. 发明人 BEBBINGTON CHRISTOPHER R.;NIEDER MATTHEW H.;CARDARELLI PINA M.;GANGWAR SANJEEV;PICKFORD LESLEY B.;PAN CHIN
分类号 A61K31/704;A61K45/00;A61K47/48;A61K49/00;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07K5/06;C07K5/083;G01N33/68;(IPC1-7):C07K1/113;C12Q1/37 主分类号 A61K31/704
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