发明名称 |
Oligonucleotide delivery systems for camptothecins |
摘要 |
Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.
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申请公布号 |
US6897200(B1) |
申请公布日期 |
2005.05.24 |
申请号 |
US20010807332 |
申请日期 |
2001.05.21 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
BURKE THOMAS G.;DEMIR AYHAN S.;CHAVAN ASHOK J.;YANG DANZHOU |
分类号 |
A61K9/127;A61K31/4745;A61K47/34;A61K47/48;A61K48/00;C07D491/22;(IPC1-7):A61K48/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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