MICROBIAL METHOD FOR PRAVASTATIN PRODUCTION

摘要

FIELD: biotechnology, in particular production of antibiotic pravastatin from compactin using microbiological transformation. ^ SUBSTANCE: microbiological compactin conversion to pravastatin is carried out by cultivation of strain Mortierella maculata n. sp. E-97 capable to hydrolyze pravastatin under deep anaerobic conditions. Broth for strain cultivation contains digestible carbon and nitrogen sources and mineral salts. Pravastatin is isolated from broth and purified. In claim of invention structural formulae of compactin (formula I) and pravastatin (formula II) are provided. ^ EFFECT: industrial scale method for pravastatin production. ^ 56 cl, 1 dwg, 8 ex