发明名称 |
Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors |
摘要 |
Novel benzamide compounds of Formula (I), Formula (II) and Formula (III, salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (II) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.
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申请公布号 |
US2005107398(A1) |
申请公布日期 |
2005.05.19 |
申请号 |
US20040903771 |
申请日期 |
2004.07.30 |
申请人 |
MACH ROBERT H.;WELCH MICHAEL J.;ROWLAND DOUGLAS J.JR.;TU ZHUDE |
发明人 |
MACH ROBERT H.;WELCH MICHAEL J.;ROWLAND DOUGLAS J.JR.;TU ZHUDE |
分类号 |
A61K31/47;A61K31/495;A61K51/04;C07C323/41;C07D217/04;C07D257/02;C07D295/13;(IPC1-7):A61K31/495 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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