N<&epsiv;> AND/OR N<alpha> DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH [M(OH2)3(CO)3]<+> BY FAC COORDINATION

摘要

The present invention relates to novel histidine derivatives that can be used for the labeling of biomolecules with radioactive metal tricarbonyls. The new derivatives have a histidine that is derivatized at the N<ϵ> and at least protected at the N and optionally at the N ; or derivatized at the N and at least protected at the N and optionally at the N ; or derivatized at the N<ϵ >and N and at least protected at the N and optionally at the N ; or derivatized at the N<ϵ>; or derivatized at the N; or derivatized at the N<ϵ> and N; or at least protected at the N and optionally at the N<.delta>.