| 摘要 |
The invention comprises compounds having the general formulae <FORM:1012491/C2/1> <FORM:1012491/C2/2> wherein X represents hydrogen or a halogen atom and R represents hydrogen or a hydrocarbon group of less than ten carbon atoms and the dotted line represents a single or double bond, and a process for the preparation thereof characterized by treating a compound of the formula: <FORM:1012491/C2/3> wherein X is as defined above, with the enzymes of a micro-organism Cylindrocarpon radicola or Penicillium citrinum, and, if desired, forming the ester of the secoandrostatrienoic acid or converting the testolactone compound to the corresponding secoandrostatrienoic acid compound with a strong base. Alternatively the 11-keto-1-dehydrotestolactone may be prepared by treating the progesterone compound with Penicillium citrinum to form the corresponding 11-ketotestololactone which is then treated with a 1 - dehydrogenating micro organism, e.g. Nocardia restricus, selenium dioxide or 2,3-dichloro-5,6-dicyanobenzoquinone.
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