发明名称 |
3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same |
摘要 |
The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a beta-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group. (each of the substituents is as described in claim 1).
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申请公布号 |
US2005107621(A1) |
申请公布日期 |
2005.05.19 |
申请号 |
US20040944055 |
申请日期 |
2004.09.20 |
申请人 |
MITSUBISHI CHEMICAL CORPORATION |
发明人 |
TAKEHARA JUN;QU JINGPING;KANNO KAZUAKI;KAWABATA HIROSHI;DEKISHIMA YASUMASA;UEDA MAKOTO;ENDO KYOKO;MURAKAMI TAKESHI;SASAKI TOMOKO;UEHARA HISATOSHI;MATSUMOTO YOUICHI;SUZUKI SHIHOMI |
分类号 |
A61K31/381;C07D333/16;C07D333/22;(IPC1-7):C07D333/22 |
主分类号 |
A61K31/381 |
代理机构 |
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代理人 |
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地址 |
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