发明名称 |
NOVEL ACETOACETYL-CoA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL |
摘要 |
A process for easily producing optically active alcohols which are (R)-3-hydroxypentanenitrile, an optically active 3-hydroxybutanoic ester, and an optically active 1-phenylethanol derivative; and a novel enzyme useful for the production of the optically active alcohols, in particular, (R)-3-hydroxypentanenitrile. The enzyme is a novel acetoacetyl-CoA reductase which is capable of asymmetrically reducing 3-ketopentanenitrile to produce (R)-3-hydroxypentanenitrile having an optical purity of 99% e.e. or higher. The process comprises causing the novel enzyme or a known acetoacetyl-CoA reductase to act on each of 3-ketopentanenitrile, an acetoacetic ester, and a 1-phenylethanone derivative to produce the corresponding optically active alcohols. |
申请公布号 |
WO2005044973(A2) |
申请公布日期 |
2005.05.19 |
申请号 |
WO2004JP16666 |
申请日期 |
2004.11.10 |
申请人 |
KANEKA CORPORATION;KAWANO, SHIGERU;YASOHARA, YOSHIHIKO |
发明人 |
KAWANO, SHIGERU;YASOHARA, YOSHIHIKO |
分类号 |
C12N;C12N1/21;C12N9/02;C12N15/09;C12P7/04;C12P7/22;C12P7/42;C12P13/00;C12P41/00 |
主分类号 |
C12N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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