发明名称 |
LIQUID STABILIZED PROTEIN FORMULATIONS IN COATED PHARMACEUTICAL CONTAINERS |
摘要 |
A container comprising a closure means coated by an inert fluorinated material and containing a liquid pharmaceutical composition. In particular, the container comprises a closure means coated by TEFLON and contains a HSA-free Interferon-beta formulation having the following composition: 30 to 100 µg/ml of interferon-beta, an isotonicity agent, 0.1 to 2 mg/ml of Poloxamer 188, at least 0.12 mg/ml of L-Methionine and a buffer solution capable of maintaining the pH of the liquid formulation at a value between 3.0 and 4.0. |
申请公布号 |
WO2004100979(A3) |
申请公布日期 |
2005.05.19 |
申请号 |
WO2004EP50779 |
申请日期 |
2004.05.12 |
申请人 |
ARES TRADING S.A.;SAMARITANI, FABRIZIO;DEL RIO, ALESSANDRA |
发明人 |
SAMARITANI, FABRIZIO;DEL RIO, ALESSANDRA |
分类号 |
A61J1/00;A61J1/14;A61K38/21;A61K47/10;A61K47/18;A61K47/26 |
主分类号 |
A61J1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|