发明名称 |
Polymorphous forms of rifaximin as antibiotics |
摘要 |
<p>Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin alpha and rifaximin beta , and a poorly crystalline form named rifaximin y have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.</p> |
申请公布号 |
AU2004287601(A1) |
申请公布日期 |
2005.05.19 |
申请号 |
AU20040287601 |
申请日期 |
2004.11.04 |
申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
DARIO BRAGA;GIUSEPPE C. VISCOMI;PAOLO RIGHI;MANUELA CAMPANA;DONATELLA CONFORTINI;GOFFREDO ROSINI;VINCENZO CANNATA |
分类号 |
A61K31/44;C07D498/22;A61K31/395;A61K31/4188;A61K31/4353;A61K31/437;A61P31/00;A61P31/04 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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