发明名称 |
COMPOSITIONS FOR TREATING PATHOLOGIES THAT NECESSITATE SUPPRESSION OF GASTRIC ACID SECRETION |
摘要 |
The present invention is related to novel oral compositions comprising an irreversible gastric H<+>/K<+>-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor, pentagastrin (PG) or a PG analogue as an activator of parietal cells in the gastric lumen. In a preferred embodiment, the composition further comprises at least one agent that preserves the availability of PG in the gastric fluids, thus enabling PG to act locally in the stomach. Unexpectedly, the compositions of the present invention exhibit anti-acid activity locally in the stomach that is meal-independent, exhibit fast onset and prolonged inhibition of acid secretion. |
申请公布号 |
WO2005020879(A3) |
申请公布日期 |
2005.05.19 |
申请号 |
WO2004IB02745 |
申请日期 |
2004.08.25 |
申请人 |
VECTA LTD.;DAVID, AYELET;GLOZMAN, SABINA;PAUL, LADA |
发明人 |
DAVID, AYELET;GLOZMAN, SABINA;PAUL, LADA |
分类号 |
A61K;A61K9/20;A61K9/46;A61K9/50;A61K31/4439;A61K33/00;A61K33/10;A61K38/00;A61K38/02;A61K38/08;A61K38/16;A61K38/22;A61K45/06 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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