发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING BLOOD-BRAIN BARRIER TRANSPORT |
摘要 |
This invention provides conjugates of therapeutic or active agents with melanotransferrin or with other ligands of a melanotransferrin receptor, melanotransferrin receptor modulators, and related compositions and methods for modulating blood-brain barrier transport by providing methods of screening and selecting such conjugates, ligands, and modulators in vitro and in vivo, and methods of use of such conjugates, modulators and ligands in diagnosis and the treatment of diseases, including particularly diseases of the central nervous system or lysosomal storage diseases. |
申请公布号 |
WO03009815(A3) |
申请公布日期 |
2005.05.19 |
申请号 |
WO2002US23923 |
申请日期 |
2002.07.25 |
申请人 |
BIOMARIN PHARMACEUTICAL INC.;BELIVEAU, RICHARD;DEMEULE, MICHEL;YANG, JOSEPH;KENNARD, MALCOLM, L.;GABATHULER, REINHARDT |
发明人 |
BELIVEAU, RICHARD;DEMEULE, MICHEL;YANG, JOSEPH;KENNARD, MALCOLM, L.;GABATHULER, REINHARDT |
分类号 |
A61K45/00;A61K47/48;A61P7/02;A61P9/10;A61P25/00;A61P35/00;A61P43/00;C07K14/79;C07K16/40;C07K19/00;C12N5/08;C12Q1/02;G01N33/15;G01N33/50;G01N33/68 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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