发明名称 |
METHODS OF THERAPY FOR SOLID TUMORS EXPRESSING THE CD40 CELL-SURFACE ANTIGEN |
摘要 |
<p>Methods of therapy are provided for treating a subject for a solid tumor that comprises carcinoma cells expressing the CD40 cell-surface antigen. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a subject in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Binding of the anti-CD40 antibody or suitable antigen-binding fragment thereof beneficially inhibits growth of solid tumors via ADCC-dependent killing of the CD40-expressing carcinoma cells.</p> |
申请公布号 |
CA2544852(A1) |
申请公布日期 |
2005.05.19 |
申请号 |
CA20042544852 |
申请日期 |
2004.11.04 |
申请人 |
CHIRON CORPORATION |
发明人 |
ZAROR, ISABEL;YABANNAVAR, ASHA;LUQMAN, MOHAMMAD;LONG, LI |
分类号 |
A61K39/395;A61P35/00;C07K16/20;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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