COMPOSITIONS AND METHODS TO MODULATE AN IMMUNE RESPONSE TO AN IMMUNOGENIC THERAPEUTIC AGENT

摘要

Methods and compositions for modulating an immune response to an immunogenic
therapeutic agent are disclosed. One of the disclosed methods comprises
administering an effective amount of CTLA-4 to decrease the incidence and/or
severity of an immune reaction in conjunction with the administration of a
potentially immunogenic substance. Another method contemplates tolerizing a
subject to a therapeutic molecule that is or is capable of being immunogenic
by the administration of CTLA-4. Various embodiments of CTLA-4 are also
disclosed.