Synthetic gene comprising dispersed or foreign deoxyribonucleic molecule and a gene construct containing such a synthetic gene

摘要

In the present invention, there is disclosed a synthetic gene containing a dispersed or foreign deoxyribonucleic molecule, said gene comprising at least two copies of a structural gene sequence where at least 80 percent of the first copy of the structural gene sequence is identical with a nucleotide sequence being complementary to a target gene section, and wherein the synthetic gene is capable of producing a post-transcription repression, delay or another reduction of said target gene expression if exprimed in a host cell of a mammal by sequentially-specific degradation of RNA transcription of the target gene by an endogenous host cell system. The present invention also relates to a gene construct containing such a synthetic gene. The synthetic genes and gene constructs according to the present invention are capable to suppress, delay of in another way to reduce expression of an endogenous gene or a target gene in an organism in which they are introduced.