Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. Formula (I) One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC(TM) 43491 or a mutant or variant such as the strain IDAC-220604-1. Another method for obtaining the compounds is post-biosynthesis chemical modification of the compounds obtained by cultivation. Novel polynucleotide sequences and encoded proteins for the biosynthesis of the polyene polyketides are also presented.
申请公布号
WO2005024025(A8)
申请公布日期
2005.05.19
申请号
WO2004CA01603
申请日期
2004.09.10
申请人
MCALPINE, JAMES, B.;FARNET, CHRIS, M.;ZAZOPOULOS, EMMANUEL;SORENSEN, DAN;ECOPIA BIOSCIENCES INC.
发明人
MCALPINE, JAMES, B.;FARNET, CHRIS, M.;ZAZOPOULOS, EMMANUEL;SORENSEN, DAN