| 摘要 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and is a double bond; or X is CH, Y is CH<SUB>2 </SUB>or oxygen and is a single bond; or X is nitrogen, Y is CH<SUB>2 </SUB>and is a single bond; is halogen, hydroxy, cyano, C<SUB>1-6</SUB>alkyl, haloC<SUB>1-6</SUB>alkyl or C<SUB>1-6</SUB>alkoxy; a is 0, 1, 2, 3 or 4; R2 and R3, together with the nitrogen atom to which they are attached, form a nitro group or an optionally substituted 3 to 7 membered heterocyclic group, or R2 and R3 are independently hydrogen, aroyl, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkanoyl, fluoroC<SUB>1-6</SUB>alkanoyl, C<SUB>1-6</SUB>alkylsulfonyl, fluoroC<SUB>1-6</SUB>alkylsulfonyl, carbamoyl, C<SUB>1-6</SUB>alkylcarbamoyl, arylC<SUB>1-6</SUB>alkyl or a group CO(CH<SUB>2</SUB>)bNR4R5 wherein b is 1, 2, 3 or 4; and R4 and R5 are independently hydrogen or C<SUB>1-6</SUB>alkyl, or R4 and R5, together with the nitrogen atom to they are attached, form part of an optionally substituted 3 to 7 membered heterocyclic group. Methods of preparing the compounds and uses of the compounds in therapy, in particular for CNS disorders such as depression and anxiety, are also disclosed.
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