| 摘要 |
<p>An orthopoxvirus vector, such as vaccinia, is described in which the A52R protein from vaccinia, or a closely related protein from any orthopoxvirus is not expressed or is expressed but is non-functional. Also described is the use of a vaccinia virus A52R protein or a closely related protein from any orthopoxvirus, or a functional peptide, peptidometic, fragment or derivative thereof, or a DNA vector expressing any of the above in the modulation and/or inhibition of IL1R/TLR superfamily signalling.</p> |
| 申请人 |
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;O'NEILL, LUKE, ANTHONY, JOHN;BOWIE, ANDREW, GRAHAM;HARTE, MARY, THERESA;SMITH, GEOFFREY, LILLEY;HAGA, ISMAR, ROCHA;MALONEY, GERALDINE |
发明人 |
O'NEILL, LUKE, ANTHONY, JOHN;BOWIE, ANDREW, GRAHAM;HARTE, MARY, THERESA;SMITH, GEOFFREY, LILLEY;HAGA, ISMAR, ROCHA;MALONEY, GERALDINE |
