发明名称 |
DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER |
摘要 |
Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab. |
申请公布号 |
CA2566823(A1) |
申请公布日期 |
2005.05.19 |
申请号 |
CA20042566823 |
申请日期 |
2004.11.05 |
申请人 |
BOARD OF REGENTS - THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SAHIN, AYSEGUL A.;NAGATA, YOICHI;YU, DIHUA;ESTEVA, FRANCISCO J.;ZHOU, XIAOYAN |
分类号 |
C07H21/04;A61B;C12N15/00;C12Q1/42;C12Q1/68;G01N33/50;G01N33/573;G01N33/574 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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