发明名称 |
12 amino acid sequence |
摘要 |
The present invention relates to an isolated target sequence. The target sequence is a splice variant of PDE5 called a PDE5a1, a component of which is presented as SEQ ID No 1. The identified target sequence of the present invention may be used to as a target to identify agents (such as modulators) useful in the prevention and/or treatment of a disease associated with scarring and/or fibrosis or to selectively identify smooth muscle cells and myofibroblasts and myoepithelial cells in samples of normal and diseased tissue from individuals.
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申请公布号 |
US2005106638(A1) |
申请公布日期 |
2005.05.19 |
申请号 |
US20040929745 |
申请日期 |
2004.08.30 |
申请人 |
PFIZER INC. |
发明人 |
PARUMS DINAH;PHILLIPS STEPHEN C.;RIDDEN JOHN |
分类号 |
G01N33/50;A61K35/76;A61K38/00;A61K38/46;A61K39/395;A61K45/00;A61K48/00;A61P1/00;A61P1/16;A61P9/00;A61P9/10;A61P11/00;A61P13/12;A61P17/00;A61P25/00;A61P29/00;A61P35/00;A61P43/00;C07K14/47;C07K16/18;C07K16/40;C12N9/16;C12N15/09;C12N15/55;C12Q1/44;G01N33/15;G01N33/53;G01N33/68;(IPC1-7):C12Q1/68;G01N33/567;C07H21/04 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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