发明名称 |
Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders |
摘要 |
Provided are napthoquinone-type compounds which can be used to modulate the aggregation of protein (e.g. tau) associated with neurodegenerative disease (e.g. Alzheimer's disease). Structure-function characteristics for oxidised and reduced napthoquinone-type compounds, such as menadione-related compounds, are disclosed. The invention further provides methods of treatment or prophylaxis of neurodegenerative diseases and/or clinical dementias based on the compounds.
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申请公布号 |
US2005107472(A1) |
申请公布日期 |
2005.05.19 |
申请号 |
US20040483266 |
申请日期 |
2004.12.23 |
申请人 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN |
发明人 |
WISCHIK CLAUDE M.;HORSLEY DAVID;RICKARD JANET E.;HARRINGTON CHARLES R. |
分类号 |
A61P1/16;A61K31/122;A61K31/192;A61K31/222;A61K31/255;A61P3/10;A61P7/02;A61P9/00;A61P25/00;A61P25/14;A61P25/16;A61P25/28;A61P29/00;A61P31/00;A61P35/00;A61P43/00;C07C50/10;C07C50/14;C07C50/24;C07C50/32;C07C50/38;C07C65/11;C07C69/16;C07C255/52;C07C305/22;C07C309/25;(IPC1-7):A61K31/185;A61K31/12;A61K31/19 |
主分类号 |
A61P1/16 |
代理机构 |
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代理人 |
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地址 |
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