发明名称 |
METHODS FOR REDUCING SEIZURE-INDUCED NEURONAL DAMAGE |
摘要 |
This invention provides a method for treating a subject either during or soon after a seizure, in order to reduce the extent of neuronal damage in the subject resulting from the seizure comprising administering to the subject, either during or soon after the seizure, a therapeutically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to thereby reduce the extent of neuronal damage in the subject. This invention further provides a method for inhibiting neuronal damage which would otherwise result from a seizure in a subject predisposed to having a seizure, comprising administering to the subject a prophylactically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to inhibit neuronal damage which would otherwise result from a seizure in the event the subject were to suffer a seizure. This invention further provides related articles of manufacture. |
申请公布号 |
WO2005042782(A1) |
申请公布日期 |
2005.05.12 |
申请号 |
WO2004US36173 |
申请日期 |
2004.10.28 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK;YAN, SHI DU;MCKHANN, GUY;STERN, DAVID |
发明人 |
YAN, SHI DU;MCKHANN, GUY;STERN, DAVID |
分类号 |
A01K67/027;A61K48/00;C07H21/04;C07K14/705;C12N15/85;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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