Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

摘要

The present invention is directed to compounds of the formula I: (wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2. The present invention is also directed to intermediates useful in the preparation of formula I compounds.