发明名称 |
Nucleic acid sequences and methods for identifying compounds that affect RNA/RNA binding protein interactions and mRNA functionality |
摘要 |
Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment.
|
申请公布号 |
US2005100942(A1) |
申请公布日期 |
2005.05.12 |
申请号 |
US20040963062 |
申请日期 |
2004.10.12 |
申请人 |
GIORDANO ANTHONY;XAVIER ASISH |
发明人 |
GIORDANO ANTHONY;XAVIER ASISH |
分类号 |
C07H21/02;C07H21/04;C12N9/22;C12P19/34;C12P21/04;C12Q1/00;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|