发明名称 |
METHODS AND COMPOSITIONS FOR THE INHIBITION OF MODULATION OF T CELL COSTIMULATORY PATHWAY BY A PATHOGENIC AGENT |
摘要 |
The invention relates to methods and compositions for the inhibition of modulation of T cell costimulatory pathway by a pathogenic agent. More particularly, the invention relates to the inhibition of activation of a T cell costimulatory pathway, preferably, the CD28/B7 pathway, by a pyrogenic exotoxin. The method of the invention is based on the inhibition of the direct interaction of a superantigen with a specific site within the dimer interface of a CD28 family member, using immunomodulatory peptides. The invention further provides specific antagonist immunomodulatory peptides comprising an amino acid sequence derived from a dimer interface of a T cell costimulatory pathway member. Alternatively, said peptide comprises an amino acid sequence which specifically binds to an amino acid sequence within the dimer interface of a T cell costimulatory pathway member. Compositions comprising said peptides and methods for the treatment of immune-related disorders are also provided by the invention.. |
申请公布号 |
WO2004087196(A3) |
申请公布日期 |
2005.05.12 |
申请号 |
WO2004IL00299 |
申请日期 |
2004.04.01 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW;KAEMPFER, RAYMOND;ARAD, GILA |
发明人 |
KAEMPFER, RAYMOND;ARAD, GILA |
分类号 |
A61K38/17;C07K7/06;C07K7/08;C07K14/705;G01N33/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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