TASPASEL 1 AND METHODS OF USE

摘要

A novel protease, Taspase (1), is described. Taspase (1) is involved in the cleavage of the MLL protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase (1) are provided, as well as inhibitors of Taspase (1). Methods of using the inhibitors of Taspase (1) are also described. For example an inhibitor of Taspase (1) can be used to treat a cancer, e.g., leukemia, in a subject.