It is intended to provide an HLA-E chimeric molecule which inhibits the cytotoxic activity of human NK cells in non-human mammalian cells; a base sequence encoding this chimeric molecule; a non-human mammalian cell transformed by this base sequence; and the corresponding mammal. The above-described HLA-E chimeric molecule is a peptide in which the signal peptide domain, the alpha1 domain and/or the alpha2 domain of HLA-E have been entirely or partly modified. The above-described base sequence is a base sequence encoding this chimeric molecule. A transformant having the above-described base sequence transferred thereinto has an effect of effectively expressing HLA-E.
申请公布号
WO2005042693(A2)
申请公布日期
2005.05.12
申请号
WO2004JP16776
申请日期
2004.11.04
申请人
THE ANIMAL ENGINEERING RESEARCH INSTITUTE;MIYAGAWA, SHUJI;MATSUNAMI, KATSUYOSHI