Vascular stent or graft coated or impregnated with protein tyrosine kinase inhibitors and methods of using same.

摘要

Disclosed is a device, such as a cardiovascular stent, autologous venous/arterial graft, prosthetic venous/arterial graft, vascular catheter, or vascular shunt, for stenting a blood vessel, The device has coated thereon, adsorbed thereto, impregnated therein, or covalently or ionically bonded thereto an amount of a protein tyrosine kinase inhibitor. The protein tyrosine kinase inhibitor inhibits proliferation of vascular smooth muscle cells in an area within a blood vessel immediately adjacent to and/or proximal to the device, while simultaneously not inhibiting the proliferation of vascular intimal cells. A corresponding method of using the device to stent blood vessels is also disclosed.