PRODRUGS OF DIARYL-2-(5H)-FURANONE CYCLOOXYGENASE-2 INHIBITORS
摘要
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. These prodrugs are far more soluble in aqueous media than the active agents into which they convert, in vivo. As such compounds of Formula (I) and (II) are advantageous for, among other things intravenous administration. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) and Formula (II).
申请公布号
WO2005042476(A2)
申请公布日期
2005.05.12
申请号
WO2004US34374
申请日期
2004.10.18
申请人
MERCK & CO., INC.;ARRUDA, JEANNIE, M.;MUNOZ, BENITO;STEARNS, BRIAN, A.
发明人
ARRUDA, JEANNIE, M.;MUNOZ, BENITO;STEARNS, BRIAN, A.