发明名称 Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
摘要 Methods for detecting acetylcholinesterase in a brain of a patent, comprising administering to the patient a detectable amount of a radiolabeled compound of a class of benzisoxazoles or a pharmaceutically acceptable salt thereof, are disclosed herein. The methods are useful for diagnosing, estimating the severity of, or monitoring the progression of a dementia, such as Alzheimer's disease, in a patient. In a preferred embodiment, the benzisoxazole is:
申请公布号 US2005100509(A1) 申请公布日期 2005.05.12
申请号 US20040811046 申请日期 2004.03.26
申请人 PFIZER PRODUCTS, INC. 发明人 FROST J. J.;DANNALS ROBERT F.;MUSACHIO JOHN;SCHEFFEL URSULA;VILLALOBOS ANABELLA;BENCHERIF BADREDDINE
分类号 A61K51/00;A61K51/04;(IPC1-7):A61K49/00;A61K31/474;A61K31/454 主分类号 A61K51/00
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