发明名称 |
PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV |
摘要 |
A compound represented by the formula wherein R<1> and R<2> are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted hydroxy group; R<3> is an optionally substituted aromatic group; R<4> is an optionally substituted amino group; L is a divalent chain hydrocarbon group; Q is a bond or a divalent chain hydrocarbon group; and X is a hydrogen atom, a cyano group, a nitro group, an acyl group, a substituted hydroxy group, an optionally substituted thiol group, an optionally substituted amino group or an optionally substituted cyclic group; provided that when X is an ethoxycarbonyl group, then Q is a divalent chain hydrocarbon group. The compound has a peptidase inhibitory action, is useful as an agent for the prophylaxis or treatment of diabetes and the like, and is superior in efficacy, duration of action, specificity, lower toxicity and the like. |
申请公布号 |
WO2005042488(A1) |
申请公布日期 |
2005.05.12 |
申请号 |
WO2004JP16457 |
申请日期 |
2004.10.29 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED;OI, SATORU;MAEZAKI, HIRONOBU;SUZUKI, NOBUHIRO |
发明人 |
OI, SATORU;MAEZAKI, HIRONOBU;SUZUKI, NOBUHIRO |
分类号 |
C07D213/12;C07D213/55;C07D213/56;C07D213/59;C07D213/71;C07D213/75;C07D213/80;C07D213/82;C07D401/06;C07D401/12;C07D405/12;C07D409/12;C07D413/06;C07D413/12;C07F9/40;C07F9/58 |
主分类号 |
C07D213/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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