发明名称 |
CARBAMOYL ESTERS THAT INHIBIT CHOLINESTERASE AND RELEASE PHARMACOLOGICALLY ACTIVE AGENTS |
摘要 |
Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: Formula (I)wherein A is selected from the group consisting of an unsubstituted aryl, a substituted aryl, an unsubstituted heteroaryl and a substituted heteroaryl. The carbamoyl esters are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the carbamoyl esters can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine. |
申请公布号 |
WO2005042475(A2) |
申请公布日期 |
2005.05.12 |
申请号 |
WO2004US34548 |
申请日期 |
2004.10.19 |
申请人 |
SENTION, INC.;VERHEIJEN, JEROEN, C.;DU, SHOUCHENG |
发明人 |
VERHEIJEN, JEROEN, C.;DU, SHOUCHENG |
分类号 |
C07C271/40;C07C271/42;C07C271/44;C07C271/48;C07D213/64;C07D487/04;C07D519/00 |
主分类号 |
C07C271/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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