<p>The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Abeta42 peptide of human amyloid-beta precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human AbetaIowa peptide of human amyloid-beta precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.</p>
申请公布号
WO2005041650(A1)
申请公布日期
2005.05.12
申请号
WO2004US34838
申请日期
2004.10.21
申请人
ENVIVO PHARMACEUTICALS, INC.;LOWE, DAVID, A.;CUMMINGS, CHRISTOPHER, J.;KEONIG, GERHARD
发明人
LOWE, DAVID, A.;CUMMINGS, CHRISTOPHER, J.;KEONIG, GERHARD