ENDOTHELIASE-1 LIGANDS

摘要

The disclosure describes compounds that can include a peptide or Kunitz domain that binds endotheliase 1 (ET1). The compounds can be used, e.g., to reduce angiogenesis in a subject having or at risk for a neoplastic disorder, modulate the activity of an ET1-expressing cell, modulate proteolysis of a biological structure, detect endotheliase activity or protein in a sample, and detect ET1 protein in a subjects.