INDUCING A T CELL RESPONSE WITH RECOMBINANT PESTIVIRUS REPLICONS OR RECOMBINANT PESTIVIRUS REPLICON-TRANSFECTED DENDRITIC CELLS

摘要

The present disclosure relates to compounds and methods of generating T cell-mediated immunity, particularly T cell-mediated immunity to Hepatitis C Virus (HCV), Respiratory Syncytial Virus (RSV), Human Immunodeficiency Virus (HIV), Mycobacterium tuberculosis, Plasmodium falciparum, and tumors. The method includes (a) administering to the subject an amount of an antigen presenting cell (such as dendritic cell) sufficient to induce the response in the subject, wherein the antigen presenting cell expresses the antigen from apestivirus replicon or (b) directly administering the antigen expressing replicon in form of RNA or DNA.